Key result
Transcardiac cTnT release was significantly higher in LGE-positive patients with nonischemic heart failure compared to LGE-negative patients (4.3 vs 1.5 ng/L; p=0.001).
Why the study?
Does the extent of myocardial fibrosis assessed by CMR correlate with transcardiac troponin T release in patients with nonischemic heart failure?
Observational (n=74)
Does the extent of myocardial fibrosis assessed by CMR correlate with transcardiac troponin T release in patients with nonischemic heart failure?
Absolute Event Rate: 4.3% vs 1.5%
p-value: p=0.001
In patients with nonischemic heart failure, the extent of myocardial fibrosis on CMR correlates with transcardiac release of high-sensitivity troponin T, suggesting ongoing myocardial damage.
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Suggests ongoing injury in fibrotic nonischemic HF; hypothesis-generating, needs prospective validation before practice change.
Takashio et al. (2014) conducted an observational in Nonischemic heart failure (n=74). Myocardial fibrosis (LGE-positive on CMR) vs. No myocardial fibrosis (LGE-negative on CMR) was evaluated on Transcardiac cTnT release (ΔcTnT [CS-Ao]) (p=0.001). Transcardiac cTnT release was significantly higher in LGE-positive patients with nonischemic heart failure compared to LGE-negative patients (4.3 vs 1.5 ng/L; p=0.001).
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