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January 1, 2010Clinical Medicine Insights TherapeuticsOpen Access

Present and Prospective Clinical Therapeutic Options for the Elderly Patient with Hypertension

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Key result

Antihypertensive drug therapy reduces the risk of cardiovascular complications and end-organ damage in elderly patients, requiring individualized therapy choices based on co-morbidities.

Why the study?

Does antihypertensive therapy reduce cardiovascular morbidity and mortality in elderly patients with hypertension?

Population

Elderly patients (aged 65 years and older) with hypertension

Comparison

Antihypertensive therapy vs Placebo or no treatment

Design

Review

Authors

MLMonika LechleitnerFHFriedrich Hoppichler

Discussion

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Overview

Supports individualized antihypertensive therapy in elderly patients; leaves open optimal regimens amid contemporary comorbidities.

Structured PICO

Does antihypertensive therapy reduce cardiovascular morbidity and mortality in elderly patients with hypertension?

P
Population
Elderly patients (aged 65 years and older) with hypertension
I
Intervention
Antihypertensive therapy (including diuretics, beta-blockers, ACE-inhibitors, angiotensin II-AT1-receptor blockers, calcium channel blockers, alpha-adrenergic receptor antagonists, centrally acting drugs and vasodilators)
C
Comparator
Placebo or no treatment (as referenced in the HYVET study)
O
Outcome
Cardiovascular morbidity and mortalityhard clinical

Antihypertensive therapy is effective in reducing cardiovascular morbidity and mortality in elderly patients, including those aged 80 years and older, though therapy must be individualized due to comorbidities and age-related changes.

Cite This Study

Lechleitner et al. (2010) conducted a review in Hypertension. Antihypertensive therapy was evaluated. Antihypertensive drug therapy reduces the risk of cardiovascular complications and end-organ damage in elderly patients, requiring individualized therapy choices based on co-morbidities.

synapsesocial.com/papers/6a98675af524c8b2cd24bd0chttps://doi.org/10.4137/cmt.s2110
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Also Consider

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  1. 1Subgroup and Per-Protocol Analysis of the Randomized European Trial on Isolated Systolic Hypertension in the Elderly1998 · 134 citations
  2. 2Renin-angiotensin-aldosterone system in the elderly: rational use of aliskiren in managing hypertension2009 · 9 citations
  3. 3Long-Term Fatal Outcomes in Subjects With Stroke or Transient Ischemic Attack2008 · 30 citations
  4. 4Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension2007 · 58 citations
  5. 5Does a change in angiotensin II formation caused by antihypertensive drugs affect the risk of stroke?2007 · 41 citations