Key result
Native T1 values sampled by a conservative septal region of interest correlated more strongly with interstitial myocardial fibrosis (r=0.59, p<0.01) than those sampled from the entire short-axis slice.
Why the study?
Does T1 mapping with a conservative septal ROI improve correlation with histological interstitial myocardial fibrosis compared to a short-axis ROI in patients with severe aortic stenosis?
Cross-Sectional (n=24)
No
Does T1 mapping with a conservative septal ROI improve correlation with histological interstitial myocardial fibrosis compared to a short-axis ROI in patients with severe aortic stenosis?
Effect estimate: r=0.59
Absolute Event Rate: 0.59% vs 0.36%
p-value: p=<0.01
Native T1 mapping using a conservative septal ROI provides the strongest correlation with histological interstitial myocardial fibrosis in patients with severe aortic stenosis.
Septal ROI may be preferred for native T1 in severe AS; leaves open whether it refines clinical decisions or outcomes.
Background Accumulation of diffuse interstitial myocardial fibrosis in severe aortic stenosis relates to left ventricular (LV) functional impairment and determines the postoperative outcome in these patients. T1 mapping has been proposed for non-invasive quantification of diffuse interstitial fibrosis. We examined associations between T1 values and collagen volume fraction from endomyocardial biopsies from patients with severe aortic stenosis. We compared whether these relationships differ with respect to the post-processing approach.
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Child et al. (2015) conducted a cross-sectional in Severe aortic stenosis (n=24). Conservative septal ROI for T1 mapping vs. Entire midventricular short-axis (SAX) slice ROI was evaluated on Pearson correlation of native T1 values with collagen volume fraction (CVF) (r=0.59, p=<0.01). Native T1 values sampled by a conservative septal region of interest correlated more strongly with interstitial myocardial fibrosis (r=0.59, p<0.01) than those sampled from the entire short-axis slice.
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