Why the study?
Does CMR with T1 mapping correlate with LV remodeling patterns and NT-pro-BNP in patients with severe symptomatic aortic stenosis?
Does CMR with T1 mapping correlate with LV remodeling patterns and NT-pro-BNP in patients with severe symptomatic aortic stenosis?
Native T1 mapping and extracellular volume fraction correlate with abnormal LV remodeling patterns and NT-pro-BNP in severe aortic stenosis, suggesting utility in assessing myocardial changes.
Background Aortic stenosis (AS) appears to be not just a disease of the valve, with adaptive and maladaptive myocardial remodeling playing a key role. Left ventricular (LV) remodeling in AS is characterized by cellular hypertrophy and diffuse myocardial fibrosis. Macroscopic patterns differ between patients: as hypertrophy increases, the pattern changes from normal to concentric remodeling, concentric hypertrophy and finally decompensation. T1 mapping allows non-invasive estimation of diffuse myocardial fibrosis (native T1 and extracellular volume fraction; ECV). We use this methodology to investigate and correlate macroscopic and tissue level patterns of LV remodeling in AS patients prior to aortic valve replacement (AVR) as part of a larger outcome study (RELIEF-AS Study: NCT 02174471).
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Treibel et al. (2015) studied this question.
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