Key result
A Systolic Dyssynchrony Index greater than 10.3% derived from cardiac magnetic resonance imaging strongly predicted left ventricular reverse remodeling post-CRT, with a sensitivity of 0.88 and specificity of 0.91.
Why the study?
Does the Systolic Dyssynchrony Index derived from CMR predict left ventricular remodeling in heart failure patients undergoing CRT?
Observational (n=42)
Yes
Does the Systolic Dyssynchrony Index derived from CMR predict left ventricular remodeling in heart failure patients undergoing CRT?
Effect estimate: Sensitivity 0.88, Specificity 0.91
p-value: p=<0.0001
CMR-derived Systolic Dyssynchrony Index is highly predictive of left ventricular reverse remodeling and may improve patient selection for cardiac resynchronization therapy.
It is known that 30-40% of heart failure patients that undergo cardiac resynchronization therapy (CRT) do not derive significant clinical benefit. Using cine imaging a measure of volume change over the cardiac cycle can be derived called the Systolic Dyssynchrony Index (SDI). This has the potential to improve patient selection pre CRT.
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Duckett et al. (2011) conducted an observational in Heart failure (n=42). Systolic Dyssynchrony Index (SDI) > 10.3% vs. SDI < 10.3% was evaluated on Reduction in end systolic volume (ESV) ≥ 15% at 6 months (Sensitivity 0.88, Specificity 0.91, p=<0.0001). A Systolic Dyssynchrony Index greater than 10.3% derived from cardiac magnetic resonance imaging strongly predicted left ventricular reverse remodeling post-CRT, with a sensitivity of 0.88 and specificity of 0.91.
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