Key result
Heavy alcohol consumption (≥200 g/week) increased the risk of composite adverse events in patients with atrial fibrillation compared to abstainers/rare drinkers (aHR 1.32; 95% CI 1.06-1.66).
Why the study?
The study was conducted to determine the relationship between alcohol consumption and AF-related adverse events in patients with atrial fibrillation.
Does heavy alcohol consumption increase the risk of adverse events in patients with nonvalvular atrial fibrillation compared to abstainers?
Observational (n=9,411)
Does heavy alcohol consumption increase the risk of adverse events in patients with nonvalvular atrial fibrillation compared to abstainers?
Hazard Ratio: 1.32 (95% CI 1.06–1.66)
Heavy alcohol consumption (≥200 g/week) is associated with an increased risk of adverse cardiovascular events in patients with nonvalvular atrial fibrillation, whereas light to moderate consumption is not.
Heavy alcohol may raise adverse events in AF; leaves open causality and intervention effects for trials.
AIMS: The aim of this study is to determine the relationship between alcohol consumption and atrial fibrillation (AF)-related adverse events in the AF population. METHODS AND RESULTS: A total of 9411 patients with nonvalvular AF in a prospective observational registry were categorized into four groups according to the amount of alcohol consumption-abstainer-rare, light (<100 g/week), moderate (100-200 g/week), and heavy (≥200 g/week). Data on adverse events (ischaemic stroke, transient ischaemic attack, systemic embolic event, or AF hospitalization including for AF rate or rhythm control and heart failure management) were collected for 17.4 ± 7.3 months. A Cox proportional hazard models was performed to calculate hazard ratios (HRs), and propensity score matching was conducted to validate the results. The heavy alcohol consumption group showed an increased risk of composite adverse outcomes [adjusted hazard ratio (aHR) 1.32, 95% confidence interval (CI) 1.06-1.66] compared with the reference group (abstainer-rare group). However, no significant increased risk for adverse outcomes was observed in the light (aHR 0.88, 95% CI 0.68-1.13) and moderate (aHR 0.91, 95% CI 0.63-1.33) groups. In subgroup analyses, adverse effect of heavy alcohol consumption was significant, especially among patients with low CHA2DS2-VASc score, without hypertension, and in whom β-blocker were not prescribed. CONCLUSION: Our findings suggest that heavy alcohol consumption increases the risk of adverse events in patients with AF, whereas light or moderate alcohol consumption does not.
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Lim et al. (2020) conducted an observational in nonvalvular atrial fibrillation (n=9,411). Heavy alcohol consumption (≥200 g/week) vs. Abstainer-rare group was evaluated on composite adverse outcomes (ischaemic stroke, transient ischaemic attack, systemic embolic event, or AF hospitalization) (aHR 1.32, 95% CI 1.06-1.66). Heavy alcohol consumption (≥200 g/week) increased the risk of composite adverse events in patients with atrial fibrillation compared to abstainers/rare drinkers (aHR 1.32; 95% CI 1.06-1.66).
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