Key result
Corrected tetralogy of Fallot was associated with significantly lower global left ventricular longitudinal, circumferential, and area strains compared to healthy controls.
Why the study?
Aortopathy is common in TOF, and the relationship between LV deformation abnormalities and aortic stiffness in corrected TOF remained to be evaluated using 3D speckle-tracking echocardiography.
Do left ventricular strains correlate with aortic elastic properties in adult patients with corrected tetralogy of Fallot compared to healthy controls?
Observational (n=67)
Do left ventricular strains correlate with aortic elastic properties in adult patients with corrected tetralogy of Fallot compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Adults with corrected tetralogy of Fallot exhibit significant left ventricular deformational abnormalities that correlate with aortic stiffness, with early total reconstruction showing better LV strain parameters than early palliation-late correction.
BACKGROUND: Aortopathy is a common phenomenon in tetralogy of Fallot (TOF). The current study was designed to detect left ventricular (LV) deformation abnormalities and its relation to aortic stiffness in corrected TOF (cTOF) using the novel three-dimensional (3D) speckle-tracking echocardiography (3DSTE). Detailed comparative analysis between patients with early palliation-late correction (pcTOF) and early total reconstruction (etrTOF) was also performed. METHODS: The present study consisted of 28 cTOF patients (35.0±15.7 years, 11 males) from which 15 and 13 proved to be pcTOF and etrTOF, respectively. Their clinical parameters were compared to those of 39 matched healthy adults (35.5±6.0 years, 16 males). RESULTS: cTOF patients showed significantly lower global LV longitudinal, circumferential and area strains as compared to controls. In etrTOF patients, global LV 3D strain was higher than in controls. In pcTOF patients, all LV strains proved to be significantly lower as compared to those of etrTOF patients and controls. In all cTOF patients, several moderate correlations could be detected between LV strain parameters and aortic elastic properties. CONCLUSIONS: Significant LV deformational abnormalities could be demonstrated in cTOF patients. etrTOF patients have beneficial LV strain parameters as compared to those of pcTOF patients. LV strains show correlations with aortic elastic properties.
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Rácz et al. (2021) conducted an observational in Corrected tetralogy of Fallot (n=67). Corrected tetralogy of Fallot vs. Healthy adults was evaluated on Left ventricular strains and aortic elastic properties. Corrected tetralogy of Fallot was associated with significantly lower global left ventricular longitudinal, circumferential, and area strains compared to healthy controls.
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