A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp3)H bonds by AgSCF3/K2S2O8 under mild conditions is described. The reaction has a good functional‐group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K2S2O8 plays key roles in both the activation of the C(sp3)H bond and the oxidation of AgSCF3.
No takes yet. Share an insight, caveat, or question.
Wu et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: