Key result
Radiotherapy for head and neck malignancy was associated with significantly increased common carotid intima-media thickness compared with matched controls (0.74 mm vs 0.46 mm; p<0.001).
Why the study?
Does radiotherapy to the carotid area increase the intima-media thickness of the common carotid artery in patients with head and neck malignancy?
Population
13 patients with head and neck malignancies who had completed radiotherapy to the carotid region at least 1…
Comparison
Radiotherapy to the carotid area. vs 13 healthy controls, matched for age, sex and…
Design
Cross-sectional
Authors
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May warrant carotid surveillance after head-neck radiotherapy; leaves open links to clinical events in prospective studies.
Cross-Sectional (n=26)
Does radiotherapy to the carotid area increase the intima-media thickness of the common carotid artery in patients with head and neck malignancy?
Absolute Event Rate: 0.74% vs 0.46%
p-value: p=<0.001
Radiotherapy to the head and neck significantly increases common carotid intima-media thickness independently of traditional cardiovascular risk factors, highlighting the need for cerebrovascular risk monitoring in these patients.
Shariat et al. (2008) conducted a cross-sectional in Head and neck malignancy (n=26). Radiotherapy to the carotid area vs. No history of radiotherapy (healthy controls) was evaluated on Intima-media thickness (IMT) of the common carotid artery (p=<0.001). Radiotherapy for head and neck malignancy was associated with significantly increased common carotid intima-media thickness compared with matched controls (0.74 mm vs 0.46 mm; p<0.001).
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