Key result
Childhood cancer therapy, especially head and neck radiation, is linked to higher carotid intima-media thickness.
Why the study?
Radiotherapy and some chemotherapy regimens in childhood cancer survivors may predispose to premature arterial disease detectable by carotid intima-media thickness measurement.
Does a history of childhood anticancer treatment (chemotherapy and irradiation) increase carotid intima-media thickness in young cancer survivors?
Population
74 young childhood cancer survivors and 48 age- and sex-matched controls
Comparison
Irradiated vs non-irradiated childhood cancer survivors and controls
Design
Case-control study with ultrasound measurement of carotid IMT
Authors
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Childhood anticancer treatment may elevate carotid IMT in males; leaves open whether irradiation drives premature atherosclerosis or warrants sex-specific surveillance.
Case-Control (n=122)
Does a history of childhood anticancer treatment (chemotherapy and irradiation) increase carotid intima-media thickness in young cancer survivors?
Childhood anticancer treatment, particularly head, neck, or mediastinal irradiation in males, is associated with increased carotid intima-media thickness, indicating a risk for premature carotid artery disease.
Krawczuk‐Rybak et al. (2016) conducted a case-control in Childhood cancer (n=122). Anticancer treatment during childhood (chemotherapy and/or irradiation) vs. Age- and sex-matched controls was evaluated on Intima-media thickness (IMT) in the common carotid artery, bulb, and internal carotid artery. Childhood anticancer treatment, especially mediastinum, head, or neck irradiation, was associated with higher carotid intima-media thickness compared to controls, particularly in males.
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