Why the study?
Does high-dose chemotherapy and stem cell transplantation with or without total body irradiation cause premature arterial aging in childhood cancer survivors?
Does high-dose chemotherapy and stem cell transplantation with or without total body irradiation cause premature arterial aging in childhood cancer survivors?
Childhood cancer survivors treated with total body irradiation show significant signs of premature arterial aging, including intima thickening and plaque formation, in young adulthood.
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May support targeted vascular surveillance in neuroblastoma survivors; leaves open prospective validation of TBI-related risk and interventions.
Vatanen et al. (2015) studied this question.
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