Key result
Childhood cancer survivors treated with radiotherapy had increased carotid and femoral intima-media thickness and higher t-PA and PAI-I levels compared with sibling controls.
Why the study?
Does potentially cardiovascular toxic anticancer treatment increase vascular damage in long-term childhood cancer survivors compared to sibling controls?
Population
277 adult long-term childhood cancer survivors treated with potentially cardiovascular toxic anticancer…
Comparison
History of potentially cardiovascular toxic… vs Sibling controls (n=130)
Design
Cohort
Follow-up
median 18 years (range 5 to 31 years) after treatment
Authors
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May indicate vascular damage in CCS; leaves open its clinical utility and treatment associations.
Observational (n=407)
Does potentially cardiovascular toxic anticancer treatment increase vascular damage in long-term childhood cancer survivors compared to sibling controls?
Long-term childhood cancer survivors treated with radiotherapy show signs of persistent endothelial damage and increased intima-media thickness, highlighting the need for cardiovascular risk monitoring in this population.
Brouwer et al. (2013) conducted an observational in Childhood cancer survivors (n=407). Potentially cardiovascular toxic anticancer treatment vs. Sibling controls was evaluated on Carotid- and femoral-wall intima-media thickness (IMT) and endothelial/inflammatory markers. Childhood cancer survivors treated with radiotherapy had increased carotid and femoral intima-media thickness and higher t-PA and PAI-I levels compared with sibling controls.
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