Why the study?
Vascular alterations induced by antineoplastic treatment might be a possible underlying mechanism of increased cardiovascular sequelae in childhood cancer survivors, but arterial stiffness had not been evaluated against a population-based sample.
Does a history of childhood cancer increase arterial stiffness in adult long-term survivors compared to a population-based sample?
Population
1002 long-term childhood cancer survivors and 5252 population-based Gutenberg Health Study controls
Comparison
Childhood cancer survivors vs a population-based sample
Design
Cross-sectional comparative study
Authors
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May signal heightened CV risk warranting surveillance in CCSs; leaves open causal links and intervention effects.
Does a history of childhood cancer increase arterial stiffness in adult long-term survivors compared to a population-based sample?
Long-term childhood cancer survivors exhibit significantly increased arterial stiffness compared to the general population, independent of traditional cardiovascular risk factors.
Arnold et al. (2021) studied this question.
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