Key result
Three-vessel coronary artery disease was associated with significantly higher mean severity scores for cervical (0.40 vs 0.04) and intracranial (0.53 vs 0.11) MRA lesions than zero-vessel CAD.
Why the study?
Is the severity of coronary artery disease associated with the presence of cervical and intracranial atherosclerosis and silent brain infarction?
Cross-Sectional (n=133)
Is the severity of coronary artery disease associated with the presence of cervical and intracranial atherosclerosis and silent brain infarction?
Absolute Event Rate: 0.4% vs 0.04%
Severe coronary artery disease is frequently accompanied by latent cervical and intracranial atherosclerosis as well as silent brain infarctions.
May warrant cerebrovascular imaging evaluation in severe CAD; leaves open whether screening improves outcomes.
PURPOSE: To investigate the prevalence of cervical and intracranial atherosclerosis and silent brain infarction in patients with coronary artery disease (CAD). METHODS: Cervical and intracranial atherosclerotic lesions on magnetic resonance angiography (MRA) and silent brain infarctions on magnetic resonance imaging (MRI) were investigated in comparison with the findings of coronary angiography in 133 consecutive patients with CAD. RESULTS: The mean severity scores of cervical and intracranial MRA lesions were significantly higher in the three-vessel CAD (0.40 and 0.53, respectively) than in the zero-vessel CAD group (0.04 and 0.11). The mean scores of the maximal size and multiplicity of MRI lesion were also significantly greater in the two-vessel (1.00 and 1.44) and three-vessel CAD (0.94 and 1.26) than in the zero-vessel CAD group (0.27 and 0.50). The incidence of MRA lesion was markedly higher in patients with brain MRI lesion than in those without (51.1 vs. 6.5%). CONCLUSIONS: Serious coronary artery lesions were commonly accompanied by latent atherosclerotic lesions in the cervical and intracranial arteries besides silent brain infarction in patients with CAD.
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Uekita et al. (2003) conducted a cross-sectional in Coronary artery disease (n=133). Three-vessel coronary artery disease vs. Zero-vessel coronary artery disease was evaluated on Mean severity scores of cervical MRA lesions. Three-vessel coronary artery disease was associated with significantly higher mean severity scores for cervical (0.40 vs 0.04) and intracranial (0.53 vs 0.11) MRA lesions than zero-vessel CAD.
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