Key result
Gestational diabetes mellitus was associated with significantly lower maternal serum and placental ANGPTL8 levels, and higher cord blood serum ANGPTL8 levels compared to normal glucose tolerance.
Why the study?
Gestational diabetes mellitus poses a significant health risk to pregnant women, making exploration of its potential underlying mechanisms highly desirable.
Are ANGPTL8 levels altered in maternal serum, cord blood serum, and placenta of women with gestational diabetes mellitus compared to those with normal glucose tolerance?
Population
42 pregnant women in the late third trimester and 29 age-matched non-pregnant healthy females
Comparison
Women with GDM vs women with normal glucose tolerance vs non-pregnant healthy females
Design
Observational comparative study
Authors
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ANGPTL8 alterations in GDM may support biomarker exploration; cross-sectional data leaves causal and predictive roles open.
Observational (n=71)
Are ANGPTL8 levels altered in maternal serum, cord blood serum, and placenta of women with gestational diabetes mellitus compared to those with normal glucose tolerance?
Maternal and cord blood serum ANGPTL8 levels are altered in gestational diabetes mellitus and correlate with metabolic parameters, suggesting potential utility as biomarkers for GDM and birthweight prediction.
Yuan et al. (2022) conducted an observational in Gestational Diabetes Mellitus (n=71). Gestational diabetes mellitus vs. Normal glucose tolerance was evaluated on Maternal serum, cord blood serum, and placental ANGPTL8 levels. Gestational diabetes mellitus was associated with significantly lower maternal serum and placental ANGPTL8 levels, and higher cord blood serum ANGPTL8 levels compared to normal glucose tolerance.
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