Key result
Gestational diabetes mellitus was associated with increased ANGPTL6 concentrations in arterial cord serum compared to controls (201 vs 119 ng/mL).
Why the study?
ANGPTL6 improves insulin sensitivity in animal studies, but its role in gestational diabetes mellitus and its presence in fetal circulation had not been evaluated in humans.
Observational (n=190)
Absolute Event Rate: 201% vs 119%
Serum ANGPTL6 levels are elevated in maternal and cord serum in gestational diabetes mellitus, disrupting its normal association with glucose homeostasis and fetal adiposity.
Disrupted ANGPTL6-glucose and adiposity links in GDM pregnancies warrant caution extrapolating normal data; leaves open mechanistic and biomarker roles.
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Valencia-Martínez et al. (2022) conducted an observational in Gestational diabetes mellitus (GDM) (n=190). Gestational diabetes mellitus vs. Control pregnancies was evaluated on Arterial cord serum ANGPTL6 concentration (ng/mL). Gestational diabetes mellitus was associated with increased ANGPTL6 concentrations in arterial cord serum compared to controls (201 vs 119 ng/mL).
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