Key result
Recombinant human ANGPTL8/betatrophin had no proliferation effect on MIN6 cells but significantly increased triglyceride levels in HepG2 cells (P = 0.002).
Why the study?
The role of ANGPTL8/betatrophin in promoting beta cell proliferation remains controversial, and its physiological functions and molecular targets are largely unknown.
Population
MIN6 and HepG2 cell lines
Comparison
Recombinant human ANGPTL8/betatrophin treatment
Design
In vitro laboratory study
Authors
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Challenges betatrophin proliferation claims; leaves open its hepatic lipid effects for further study.
p-value: p=0.002
Bacteria-derived recombinant human ANGPTL8/betatrophin increases triglyceride levels in HepG2 cells without promoting beta cell proliferation, supporting its role in lipid metabolism.
Xu et al. (2019) studied this question. Recombinant human ANGPTL8/betatrophin vs. DPBS-treated cells was evaluated on Triglyceride concentration in HepG2 cells and cell proliferation in MIN6 cells (p=0.002). Recombinant human ANGPTL8/betatrophin had no proliferation effect on MIN6 cells but significantly increased triglyceride levels in HepG2 cells (P = 0.002).
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