Key result
High expression of ANGPTL8/betatrophin was associated with poor overall survival in kidney renal clear cell carcinoma and uterine corpus endometrial carcinoma, but favorable prognosis in sarcoma and pheochromocytoma.
Why the study?
Little was known regarding the expression and prognostic value of the metabolic regulator ANGPTL8/betatrophin in human cancers.
Population
Cancer and normal samples from multiple databases
Comparison
ANGPTL8/betatrophin expression in cancer vs normal samples
Design
Bioinformatic database analysis
Authors
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ANGPTL8 expression was associated with differential survival across KIRC, UCEC, SARC and PCPG; leaves open its value as a prognostic biomarker.
Observational
ANGPTL8/betatrophin shows differential expression across various human cancers and may serve as a prognostic biomarker and therapeutic target.
Xu et al. (2021) conducted an observational in Human Cancers (KIRC, UCEC, SARC, PCPG). High ANGPTL8/betatrophin expression vs. Low ANGPTL8/betatrophin expression was evaluated on Overall survival and disease-free survival. High expression of ANGPTL8/betatrophin was associated with poor overall survival in kidney renal clear cell carcinoma and uterine corpus endometrial carcinoma, but favorable prognosis in sarcoma and pheochromocytoma.
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