Key result
Computational analysis identified 11 high-risk nsSNPs in ANGPTL3 and ANGPTL8 associated with various cancers, with altered expression of these proteins linked to low survival rates.
Why the study?
Angiopoietin-like proteins regulate diverse pathophysiological processes, but the role of high-risk non-synonymous single-nucleotide polymorphisms in ANGPTL3 and ANGPTL8 across various cancers was not determined.
Population
301 nsSNPs in ANGPTL3 and ANGPTL8 retrieved from databases
Design
Integrated computational analysis
Authors
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Should not change lipid therapy or cancer screening; leaves open ANGPTL3/8 as prognostic biomarkers pending functional validation.
Computational analysis identifies specific high-risk nsSNPs in ANGPTL3 and ANGPTL8 as potential prognostic biomarkers for various cancers.
Iqbal et al. (2023) studied Cancer. High-risk nsSNPs in ANGPTL3 and ANGPTL8 was evaluated on Association with cancer and survival rates. Computational analysis identified 11 high-risk nsSNPs in ANGPTL3 and ANGPTL8 associated with various cancers, with altered expression of these proteins linked to low survival rates.
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