Key result
Hospital mortality was significantly higher in patients with a complicated course of acute aortic dissection compared to those with an uncomplicated course (33.5% vs 18.6%).
Why the study?
Acute proximal aortic dissection remains a fatal thoracic aortic pathology with high hospital mortality despite surgical advances, prompting a description of perioperative tactics and evolving approaches.
How do different surgical tactics and the presence of complications affect hospital mortality in patients with acute De Bakey Type I aortic dissection?
Cohort (n=278)
No
How do different surgical tactics and the presence of complications affect hospital mortality in patients with acute De Bakey Type I aortic dissection?
Absolute Event Rate: 33.5% vs 18.6%
In acute De Bakey Type I aortic dissection, hospital mortality remains high, particularly in complicated cases, and an individualized multidisciplinary approach utilizing hemi-arch reconstruction is recommended as optimal in the peracute stage.
High mortality persists in acute De Bakey I dissection, especially complicated cases; leaves open optimal surgical tactic for prospective validation.
BACKGROUND Acute proximal aortic dissection (Stanford type A) remains the most common fatal pathology of the thoracic aorta. Despite the improvement of surgical technologies, hospital mortality after emergency surgical interventions is 17–25%, in complicated cases it can reach 80–90%. AIM OF STUDY Description of the perioperative treatment tactics adopted at the N.V. Sklifosovsky Research Institute for Emergency Medicine as well as the evolution of approaches that make it possible to obtain satisfactory hospital and long-term results in the treatment of aortic dissection. MATERIAL AND METHODS the study included 278 patients operated on from 2015 to 2021 in the acute stage of aortic dissection (less than 48 hours from the moment of manifestation of the disease). The operated patients were divided into two groups, depending on the presence of complicated forms: group A, 102 patients with uncomplicated course of the disease; group B, 176 patients with complicated course of the disease. Additionally, patients were divided depending on the level of distal reconstruction performed: group I, 83 patients, surgery was limited to prosthetics of the ascending aorta, without removing the clamp; group II, 137 patients who underwent hemi-arch surgery; group III, 58 patients, with distal reconstruction involving the aortic arch. RESULTS Total hospital mortality was 28.1%: 25.3% in group I, 29.1% in group II, 29.3% in group III. In the group of uncomplicated dissection, postoperative mortality was 18.6%, while in the group of complicated dissection it was 33.5%. CONCLUSION An integrated multidisciplinary approach with the formation of an “aortic team”, an individual approach to surgery, depending on the anatomy of the dissection and the clinical status of the patient, will improve the results of the treatment of acute aortic dissection, as the most severe and multiple organ pathology of the aorta. FINDING 1. Hospital mortality of complicated forms of dissection remains significantly higher — 33.5% versus 18.5% of uncomplicated course. 2. The most optimal method of distal reconstruction in patients with the peracute stage of dissection is an open anastomosis with the aorta using the “hemi-arch” technique. 3. If it is necessary to extend the surgical intervention on the aortic arch, a distal anastomosis in areas 0, 1, 2 with the possibility of a subsequent endovascular stage is the priority.
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Redkoborody et al. (2023) conducted a cohort in Acute proximal aortic dissection (Stanford type A) (n=278). Complicated course of disease vs. Uncomplicated course of disease was evaluated on Hospital mortality. Hospital mortality was significantly higher in patients with a complicated course of acute aortic dissection compared to those with an uncomplicated course (33.5% vs 18.6%).
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