Key result
In obese children, carotid intima-media thickness positively correlated with BMI, and insulin resistance (present in 41.9% of the cohort) was significantly higher in those with CIMT >0.5 mm.
Why the study?
Obesity is a major public health crisis, and carotid artery intima-media thickness is a recommended noninvasive screening tool for heart disease, prompting evaluation of its relationship with obesity in children and adolescents.
Does carotid intima-media thickness correlate with obesity and metabolic parameters in children and adolescents?
Cross-Sectional (n=74)
No
Does carotid intima-media thickness correlate with obesity and metabolic parameters in children and adolescents?
Carotid intima-media thickness is positively correlated with BMI, total cholesterol, triglycerides, and insulin resistance in obese children and adolescents, suggesting its utility as a screening tool for early cardiovascular risk.
CIMT may mark early risk in obese children; leaves open prospective validation before any screening role.
Background: Obesity is a significant public health crisis. Carotid artery Intima-Media Thickness (CIMT) is a new noninvasive ultrasound test that is being recommended to screen for heart disease in apparently healthy individuals. Objective: To determine the relationship between CIMT and obesity in children and adolescents. Patients and Methods: This study was a cross-sectional study, which was done on 74 obese children aged 6-18 years. This study was done at the Pediatrics Department, Zagazig University Hospitals., during the period from 2017 to 2019. All children were subjected to history taking and clinical examination. Anthropometric measurements were measured. Carotid intima-media thickness quantification was estimated. Results: The study resulted in 36 females (48.6%) and 38 males (51.4%). Children lived in rural areas 38(51.4%) and urban areas were 36 (48.6%). There was a significant increase in CIMT in obese children. Statistically significant positive correlations were observed between CIMT and BMI. Statistically significant positive correlations between CIMT and total cholesterol, triglycerides, while no statistically significant correlations were observed between CIMT and LDL, and HDL. Conclusion: There is a relationship between CIMT and obesity in children of the target population of the study and, at the same time, there also exist statistically significant positive correlations between CIMT and total cholesterol, triglycerides, and no statistically significant correlations between CIMT and LDL, and HDL. Regarding the prevalence of insulin resistance (IR) among our studied children, we found that 31 patients were IR (41.9%), while 43 were not (58.1%). Insulin resistance (IR) was statistically higher in children with CIMT > 0.5 millimeters.
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Al-Drawny et al. (2020) conducted a cross-sectional in Obesity (n=74). Obesity was evaluated on Relationship between CIMT and obesity/BMI. In obese children, carotid intima-media thickness positively correlated with BMI, and insulin resistance (present in 41.9% of the cohort) was significantly higher in those with CIMT >0.5 mm.
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