Key result
Exposure to sulfur dioxide in diabetic rats increased lipid peroxidation, altered antioxidant enzyme activities, and prolonged somatosensory evoked potential components.
Why the study?
Does sulfur dioxide exposure alter brain antioxidant status, lipid peroxidation, and somatosensory evoked potentials in diabetic rats?
Population
40 rats divided into 4 equal groups. Experimental diabetes mellitus was induced by i.v. injection of alloxan…
Comparison
10 ppm sulfur dioxide administered in an… vs Filtered air during the same time periods.
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating for SO2 effects on diabetic neuropathy; human studies required before any clinical relevance.
Does sulfur dioxide exposure alter brain antioxidant status, lipid peroxidation, and somatosensory evoked potentials in diabetic rats?
Exposure to sulfur dioxide increases lipid peroxidation, alters antioxidant enzyme activities, and affects somatosensory evoked potentials in a rat model of diabetes.
Küçükatay et al. (2003) studied Experimental diabetes (n=40). Sulfur dioxide (SO2) vs. Filtered air was evaluated on Brain antioxidant status, lipid peroxidation, and somatosensory evoked potentials (SEPs). Exposure to sulfur dioxide in diabetic rats increased lipid peroxidation, altered antioxidant enzyme activities, and prolonged somatosensory evoked potential components.