Key result
The combination of aerobic exercise and 4 weeks of SO2 exposure aggravated the negative effects of SO2 inhalation on cardiovascular function in rats.
Why the study?
The study was conducted to further explore the combined effects of exercise and sulfur dioxide exposure on cardiovascular function and the underlying mechanisms.
RCT
Randomly divided
Exercise in polluted air warrants clinical caution; leaves open human translation of rat ACE/Ang II findings.
The purpose of the study is to further explore the combined effects of exercise and sulfur dioxide (SO2) exposure on the cardiovascular function as well as the underlying mechanisms. Rats were randomly divided into 4 groups: rest group (RG), exercise group (EG), SO2 pollution group (SG) and SO2 pollution + exercise group (SEG). Changes of aortic pressure and left ventricular pressure, Ang II concentration, ACE concentration and ACE activity in rats' myocardial tissue were observed. Compared with RG, the systolic blood pressure, pulse pressure, LVSP, +dp/dtmax and -dp/dtmax of EG increased significantly, diastolic blood pressure, resting heart rate and ACE activity decreased significantly; For rats of SG, 4 weeks SO2 exposure increased LVEDP, Ang II concentration, ACE concentration and ACE activity, decreased the +dp/dtmax and -dp/dtmax; For rats of SEG, the systolic blood pressure, pulse pressure, LVSP, +dp/dtmax and -dp/dtmax decreased significantly, HR, LVEDP, Ang II concentration, ACE concentration and ACE activity increased significantly. Results indicate that, the combination of aerobic exercise and SO2 exposure can aggravate the negative effects of SO2 inhalation on cardiovascular function. Renin-angiotensin system plays an important role in mediating the negative effect of SO2 inhalation.
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Yanru et al. (2022) conducted an RCT in Sulfur dioxide (SO2) pollution exposure. Aerobic exercise and SO2 exposure vs. Rest group, exercise alone, and SO2 exposure alone was evaluated on Cardiovascular function (aortic pressure, left ventricular pressure, Ang II concentration, ACE concentration and ACE activity). The combination of aerobic exercise and 4 weeks of SO2 exposure aggravated the negative effects of SO2 inhalation on cardiovascular function in rats.
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