What question did this study set out to answer?

To examine whether ligustilide acts as an inhibitory constituent that suppresses the chemical extraction yields and biological efficacy of the herbal decoction Danggui Buxue Tang.

October 21, 2009Planta Medica

Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: A Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica sinensis

View Full Paper

Ask AI

Bookmark

Authors

YZYuzhong ZhengUniversity of Shanghai for Science and Technology RCRoy C.Y. ChoiUniversity of California, Los Angeles JLJun LiUniversity of Chinese Academy of Sciences

Discussion

Member takes

Overview

Experimental study reveals ligustilide suppresses herbal extraction and bone cell differentiation while stimulating breast cancer cells, validating traditional processing with wine.

Key Points

To examine whether ligustilide acts as an inhibitory constituent that suppresses the chemical extraction yields and biological efficacy of the herbal decoction Danggui Buxue Tang.
Quantified the chemical yields of astragaloside IV, calycosin, formononetin, and total polysaccharides extracted from Radix Astragali in the presence of ligustilide.
Evaluated osteogenic efficacy via proliferation and differentiation assays in cultured bone cells, as well as adverse proliferative effects in MCF-7 breast cancer cell cultures.
Ligustilide presence decreased the extraction amounts of astragaloside IV, calycosin, formononetin, and total polysaccharides from Radix Astragali.
Elevated ligustilide concentrations impaired the capacity of Danggui Buxue Tang to stimulate bone cell proliferation and differentiation, while triggering off-target proliferation in MCF-7 breast cancer cells.

Cite This Study

Zheng et al. (2009) studied this question.

synapsesocial.com/papers/6a9873bee1a021e57bd4b24d https://doi.org/10.1055/s-0029-1186222

View Full Paper

Ask AI

Bookmark

October 21, 2009Planta Medica

Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: A Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica sinensis

View Full Paper

Ask AI

Bookmark

Authors

YZYuzhong ZhengUniversity of Shanghai for Science and Technology RCRoy C.Y. ChoiUniversity of California, Los Angeles JLJun LiUniversity of Chinese Academy of Sciences

Discussion

Member takes

Overview

Experimental study reveals ligustilide suppresses herbal extraction and bone cell differentiation while stimulating breast cancer cells, validating traditional processing with wine.

Key Points

To examine whether ligustilide acts as an inhibitory constituent that suppresses the chemical extraction yields and biological efficacy of the herbal decoction Danggui Buxue Tang.
Quantified the chemical yields of astragaloside IV, calycosin, formononetin, and total polysaccharides extracted from Radix Astragali in the presence of ligustilide.
Evaluated osteogenic efficacy via proliferation and differentiation assays in cultured bone cells, as well as adverse proliferative effects in MCF-7 breast cancer cell cultures.
Ligustilide presence decreased the extraction amounts of astragaloside IV, calycosin, formononetin, and total polysaccharides from Radix Astragali.
Elevated ligustilide concentrations impaired the capacity of Danggui Buxue Tang to stimulate bone cell proliferation and differentiation, while triggering off-target proliferation in MCF-7 breast cancer cells.

Cite This Study

Zheng et al. (2009) studied this question.

synapsesocial.com/papers/6a9873bee1a021e57bd4b24d https://doi.org/10.1055/s-0029-1186222

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark