Key result
Ketofol provided superior hemodynamic stability compared to propofol alone, maintaining higher mean blood pressure at 5 minutes during endoscopic procedures.
Why the study?
Does ketofol improve hemodynamic and respiratory stability compared to propofol alone in patients undergoing elective endoscopy and colonoscopy?
RCT (n=100)
Double-blind
Closed envelope method
No
Does ketofol improve hemodynamic and respiratory stability compared to propofol alone in patients undergoing elective endoscopy and colonoscopy?
Ketofol provides superior hemodynamic and respiratory stability compared to propofol alone during endoscopic procedures, without delaying recovery.
Answers are grounded in this paper and cite their sources.
Supports ketofol for hemodynamic stability in endoscopy; extends RCT evidence for its use over propofol in procedural sedation.
The Effects of Propofol and Ketofol on Hemodynamics, End-Tidal Carbon Dioxide, Integrated Pulmonary Index and Recovery in Patients Undergoing Endoscopy and Colonoscopy - Cyprus Journal of Medical Sciences
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Aşkın et al. (2023) conducted an RCT in Elective upper gastrointestinal endoscopy and colonoscopy (n=100). Ketofol (ketamine and propofol mixture) vs. Propofol was evaluated on Mean blood pressure at 5 minutes after start of sedation (p=<0.001). Ketofol provided superior hemodynamic stability compared to propofol alone, maintaining higher mean blood pressure at 5 minutes during endoscopic procedures.
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