Key result
JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells and could be a target signaling pathway in cardiac regenerative therapy.
JAK-STAT signaling is a critical pathway in the differentiation of cardiac stem/progenitor cells into cardiac lineage cells, suggesting it could be a target for cardiac regenerative therapy.
Hypothesis-generating for JAK-STAT modulation in stem cell cardiac repair; should not change clinical practice.
Recently various kinds of cardiac stem/progenitor cells have been identified and suggested to be involved in cardiac repair and regeneration in injured myocardium. In this review, we focus on the roles of JAK-STAT signaling in cardiac stem/progenitor cells in cardiomyogenesis. JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells. The activation of JAK-STAT signal elicits the mobilization of mesenchymal stem cells as well, contributing to the maintenance of cardiac function. Thus we propose that JAK-STAT could be a target signaling pathway in cardiac regenerative therapy.
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Mohri et al. (2012) conducted a review in Cardiac repair and regeneration. JAK-STAT signaling pathway was evaluated. JAK-STAT signaling plays important roles in the differentiation of stem cells into cardiac lineage cells and could be a target signaling pathway in cardiac regenerative therapy.
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