What does this research mean for the field?

Mesenchymal stem cell (MSC) injection into skeletal muscle promotes cardiac repair through MSC-derived IL-6-type cytokines that activate the host tissue JAK-STAT3 signaling axis, leading to the systemic production of trophic factors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 18, 2010AJP Heart and Circulatory PhysiologyOpen Access

Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair

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Structured PICO

Population

Cultured C2C12 skeletal myocytes and failing hamster heart model

Intervention

Injection of bone marrow mesenchymal stem cells (MSCs) into the skeletal muscle

Outcome

Activation of JAK-STAT3 signaling, expression of STAT3 target genes (HGF, VEGF), and functional improvement in the diseased heartsurrogate

Injection of MSCs into skeletal muscle promotes cardiac repair via IL-6-type cytokine activation of the host JAK-STAT3 axis and subsequent release of trophic factors.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for remote MSC effects on cardiac repair; should not yet change clinical practice.

Cite This Study

Shabbir et al. (2010) studied this question.

synapsesocial.com/papers/6a1be0576f692abb725ef088 https://doi.org/10.1152/ajpheart.00488.2010

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Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair

Structured PICO

Discussion

Implication

Cite This Study

Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider