Key result
Postmortem examination and immunohistochemistry of a giant breast mass in a 16-year-old girl confirmed a rare grade 3 primary angiosarcoma.
Why the study?
Angiosarcoma located in the breast is extremely rare, accounting for less than 0.01% of cases.
Case Report (n=1)
No
Primary angiosarcoma of the breast is an exceptionally rare and aggressive tumor in adolescents, often fatal in resource-constrained settings without early detection and management.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to rare aggressive breast tumors in adolescents; extends sparse case literature on primary angiosarcoma in this age group.
BACKGROUND: Angiosarcoma is an endothelial malignant tumor; angiosarcoma located in the breast is extremely rare, less than 0.01%. We report a case of a giant angiosarcoma diagnosed postmortem in a 16-year-old girl in a resource-constrained country. CASE PRESENTATION: A 16-year-old black African girl was admitted for altered consciousness and a left breast tumor. She was admitted in a state of apparent death. Her death was confirmed on clinical examination. A postmortem biopsy of the mammary tumor showed standard histology of a proliferation of fusiform or rounded tumor cells in places, which were not very cohesive with marked anisokaryosis and numerous foci of tumor necrosis. Immunohistochemistry showed a positivity of CD31 and factor VIII markers with a proliferation index (Ki-67) estimated at 30%. CONCLUSION: Primary angiosarcoma of the breast is exceptional in adolescents and has a poor prognosis, especially in countries with limited resources.
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Darré et al. (2020) conducted a case report in Primary angiosarcoma of the breast (n=1). Primary angiosarcoma of the breast was evaluated on Histopathological and immunohistochemical diagnosis. Postmortem examination and immunohistochemistry of a giant breast mass in a 16-year-old girl confirmed a rare grade 3 primary angiosarcoma.
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