Chemical attachment of the thiol-derivatized DNA monolayers on arsenic terminated GaAs (001) has been achieved. The sulfur-As-based covalent bonds of the thiolated oligonucleotids on the arsenic terminated GaAs (001) were observed using x-ray photoelectron spectroscopy. The purpose of our work is to investigate the self-assembly of thiol-derivatized single-stranded DNA oligonucleotides (probes) on GaAs substrate. In this letter, we demonstrate that both the S–H group in the thiolated single-strand DNA, and the N–H group in the DNA bases are functional groups that can be utilized to anchor the DNA molecule, or other biological molecules on the As-terminated GaAs surface.
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Mohaddes-Ardabili et al. (2003) studied this question.
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