Key result
Brain natriuretic peptide concentrations were significantly higher in patients with confirmed heart failure than those without heart disease (median 165 vs 15 ng/L; P<0.001).
Why the study?
Does BNP measurement combined with echocardiography improve diagnostic accuracy and cost-effectiveness in patients with new symptoms of mild heart failure?
Population
252 patients with new symptoms referred by 100 general practitioners for early diagnosis of mild heart failure
Design
Cohort
Authors
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May support BNP for early mild heart failure evaluation; leaves open whether combined echocardiography improves accuracy or cost-effectiveness.
Observational (n=252)
Does BNP measurement combined with echocardiography improve diagnostic accuracy and cost-effectiveness in patients with new symptoms of mild heart failure?
Absolute Event Rate: 165% vs 15%
p-value: p=<0.001
A BNP cutoff of 50 ng/L is a cost-effective screening tool for early diagnosis of mild heart failure, significantly reducing the need for echocardiograms.
Aspromonte et al. (2006) conducted an observational in Mild heart failure (n=252). Brain natriuretic peptide (BNP) testing vs. Patients without heart disease was evaluated on Confirmed heart failure (p=<0.001). Brain natriuretic peptide concentrations were significantly higher in patients with confirmed heart failure than those without heart disease (median 165 vs 15 ng/L; P<0.001).
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