Key result
Obstructive sleep apnea and obesity in children were associated with significantly elevated plasma Ang-2 and sTie-2 levels compared to controls, which decreased after adenotonsillectomy (P<0.01).
Why the study?
Are Ang-2 and sTie-2 plasma levels elevated in children with OSA and obesity, and does treatment of OSA reduce these levels?
Population
126 children (mean age 7.4 ± 2.0 years) evaluated for obstructive sleep apnea (OSA) and obesity.
Comparison
Adenotonsillectomy (in a subset of n=14 children). vs Controls with and without obesity; pre-treatment…
Design
Cross-sectional
Authors
Loading...
Should not yet change pediatric OSA management; leaves open Ang-2/sTie-2 as biomarkers or targets pending prospective trials.
Observational (n=126)
Are Ang-2 and sTie-2 plasma levels elevated in children with OSA and obesity, and does treatment of OSA reduce these levels?
p-value: p=<0.01
Ang-2 and sTie-2 plasma levels are elevated in pediatric OSA and obesity, correlate with endothelial dysfunction and insulin resistance, and are reduced following adenotonsillectomy.
Gozal et al. (2017) conducted an observational in Obstructive sleep apnea and obesity (n=126). Obstructive sleep apnea and obesity vs. Controls with and without obesity was evaluated on Plasma Ang-2 and sTie-2 levels (p=<0.01). Obstructive sleep apnea and obesity in children were associated with significantly elevated plasma Ang-2 and sTie-2 levels compared to controls, which decreased after adenotonsillectomy (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: