Key result
The coelomic/pericardial epithelium in the vicinity of the aortic sac, rather than the proepicardium, is the origin of the distal outflow tract epicardium.
Population
Preclinical model (embryos, likely avian given the use of eggshell membrane pieces)
Comparison
Experimental techniques including construction… vs Proepicardially derived epicardium
Design
Preclinical
Authors
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Highlights epicardial heterogeneity at the arterial pole; leaves open its role in human congenital outflow tract anomalies.
The epicardium of the distal cardiac outflow tract derives from the cephalic pericardium rather than the proepicardium, highlighting cellular heterogeneity that may influence developmental remodeling at the arterial pole.
Pérez‐Pomares et al. (2003) studied this question. Experimental in vivo and in vitro techniques vs. Proepicardially derived epicardium was evaluated on Origin and properties of d-OFT epicardium. The coelomic/pericardial epithelium in the vicinity of the aortic sac, rather than the proepicardium, is the origin of the distal outflow tract epicardium.
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