Key result
Benidipine treatment normalized upregulated cardiac TGFbeta1 and ET-1 levels in insulin-resistant OLETF diabetic rats without altering blood pressure.
Why the study?
Does benidipine reduce elevated cardiac expression of TGFbeta1 and ET-1 in a diabetic rat model?
Population
Male Otsuka Long-Evans Tokushima Fatty rats at 8 weeks of age, n=48, and age-matched genetic control…
Comparison
Benidipine or hydralazine hydrochloride for 12… vs Vehicle and age-matched genetic control LETO rats
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for BP-independent effects in diabetic cardiomyopathy; leaves open translation to human insulin-resistant states.
Does benidipine reduce elevated cardiac expression of TGFbeta1 and ET-1 in a diabetic rat model?
Long-acting calcium channel blockers like benidipine may improve cardiac morphology and function in insulin-resistant states by normalizing cardiac TGFbeta1 and ET-1 expression independent of blood pressure lowering.
Jesmin et al. (2006) studied Type 2 diabetes mellitus (n=60). Benidipine vs. Vehicle, hydralazine, and LETO control rats was evaluated on Cardiac expression of TGFbeta1 and ET-1. Benidipine treatment normalized upregulated cardiac TGFbeta1 and ET-1 levels in insulin-resistant OLETF diabetic rats without altering blood pressure.
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