Why the study?
Does candesartan prevent coronary capillary remodeling in a rat model of non-insulin-dependent diabetes mellitus?
Population
Otsuka Long-Evans Tokushima Fatty rats at 20 weeks of age
Comparison
Candesartan (AT1 receptor blocker) vs Untreated OLETF rats and nondiabetic controls
Design
Preclinical
Authors
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Provides preclinical support for AT1 blockade in diabetic microvasculature; leaves open translation to human coronary disease.
Does candesartan prevent coronary capillary remodeling in a rat model of non-insulin-dependent diabetes mellitus?
In a rat model of type 2 diabetes, AT1 receptor blockade with candesartan prevents coronary capillary remodeling driven by VEGF and HIF-1alpha.
Jesmin et al. (2002) studied this question.
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