Key result
A very high 10-year cardiovascular risk score (≥10%) at a general health checkup was associated with a significantly increased risk of overall mortality (HR 21.20) compared to a low-risk score (<1%).
Why the study?
Workers are assessed for CVD risk to prevent work-related CVD, but no previous study had addressed the relationship between 10-year cardiovascular risk from general health checkups and mortality.
Does a higher 10-year cardiovascular risk score from a general health checkup predict increased overall and cardiovascular mortality?
Cohort (n=545,859)
Yes
Does a higher 10-year cardiovascular risk score from a general health checkup predict increased overall and cardiovascular mortality?
Hazard Ratio: 21.2 (95% CI 17.42–25.79)
Absolute Event Rate: 85.88% vs 3.09%
Higher 10-year cardiovascular risk assessed during general health checkups strongly and proportionally predicts both overall and cardiovascular mortality.
May flag high-mortality patients during checkups; supports predictive validity yet leaves intervention effects open.
Background: According to the occupational accident status analysis in 2020, of 1,180 occupational deaths, 463 were caused by cardiovascular disease (CVD). Workers should be assessed for CVD risk at regular intervals to prevent work-related CVD in accordance with the rules on occupational safety and health standards. However, no previous study has addressed risk and mortality. Therefore, this longitudinal study was conducted to evaluate the relationship between 10-year cardiovascular risk of the general health checkup and mortality. Methods: Revision (ICD-10) was identified. Statistical analysis was performed using Cox proportional hazards regression analysis, and the sum of the periods from the first visit to the date of death or December 31, 2019, was used as a time scale. We also performed a stratified analysis for age at baseline and sex. Results: During 5,253,627.9 person-years, 4,738 overall deaths and 654 cardiovascular deaths occurred. When the low-risk group was set as a reference, in the multivariable-adjusted model, the hazard ratios (HRs) (95% confidence interval [CI]) for overall mortality were 3.36 (2.87-3.95) in the moderate-risk group, 11.08 (9.27-13.25) in the high-risk group, and 21.20 (17.42-25.79) in the very-high-risk group, all of which were statistically significant. In cardiovascular deaths, the difference according to the risk classification was more pronounced. The HRs (95% CI) were 8.57 (4.95-14.83), 38.95 (21.77-69.69), and 78.81 (42.62-145.71) in each group. As a result of a subgroup analysis by age and sex, the HRs of all-cause mortality and cardiovascular mortality tended to be higher in the high-risk group. Conclusions: This large-scale longitudinal study confirmed that the risk of death increases with the 10-year cardiovascular risk of general health checkup.
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Jeong et al. (2022) conducted a cohort in Cardiovascular risk (n=545,859). Very high 10-year cardiovascular risk (≥10%) vs. Low 10-year cardiovascular risk (<1%) was evaluated on Overall mortality (HR 21.20, 95% CI 17.42-25.79). A very high 10-year cardiovascular risk score (≥10%) at a general health checkup was associated with a significantly increased risk of overall mortality (HR 21.20) compared to a low-risk score (<1%).
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