What question did this study set out to answer?

To examine the incidence of hemorrhage and patterns of platelet transfusion in neonates with severe thrombocytopenia admitted to intensive care.

October 20, 2009PEDIATRICS

Prospective, Observational Study of Outcomes in Neonates With Severe Thrombocytopenia

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Authors

SSSimon StanworthNHS Blood and Transplant PCPaul ClarkeUniversity of Essex TWTim WattsGuy's and St Thomas' NHS Foundation Trust

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Implication

Observational study reveals major hemorrhage is rare in neonates with severe thrombocytopenia, indicating many platelet transfusions are driven solely by laboratory thresholds.

Key Points

To examine the incidence of hemorrhage and patterns of platelet transfusion in neonates with severe thrombocytopenia admitted to intensive care.
Prospective, cross-sectional observational study across 7 neonatal intensive care units tracking daily clinical data for infants with severe neonatal thrombocytopenia (platelet count <60 × 10⁹/L).
Screened 3,652 neonatal admissions, identifying 194 cases (5%) and enrolling 169 neonates with a median gestational age of 27 weeks (IQR: 24–32 weeks) and median birth weight of 822 g (IQR: 670–1300 g).
Platelet count nadirs were <20 × 10⁹/L in 34% (n=58), 20–39 × 10⁹/L in 39% (n=64), and 40–59 × 10⁹/L in 28% (n=47) of enrolled neonates.
Major hemorrhage occurred in 9% of infants (n=15), with 87% (13 of 15) occurring in neonates <28 weeks gestational age; 73% (n=123) had minor hemorrhage and 18% (n=31) had no recorded hemorrhage.
A total of 415 platelet transfusions were administered to 69% of infants (n=116), with 81% (n=338) prompted primarily by low platelet count, increasing median platelet levels from 27 × 10⁹/L to 79 × 10⁹/L.

Cite This Study

Stanworth et al. (2009) studied this question.

synapsesocial.com/papers/6a98877bb90e878a4a237b72 https://doi.org/10.1542/peds.2009-0332

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Implication

Observational study reveals major hemorrhage is rare in neonates with severe thrombocytopenia, indicating many platelet transfusions are driven solely by laboratory thresholds.

Prospective, Observational Study of Outcomes in Neonates With Severe Thrombocytopenia

Discussion

Member takes

Implication

Key Points

Cite This Study

Prospective, Observational Study of Outcomes in Neonates With Severe Thrombocytopenia

Discussion

Member takes

Implication

Key Points

Cite This Study

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