Key result
Obesity and type-2 diabetes are associated with a complex adherence of insulin and LDL receptors on the cell membrane, which reduces insulin receptor tyrosine phosphorylation and impairs LDL clearance.
Observational (n=45)
Universality of association of two receptors, LDLR (LDL receptor) and IR (insulin receptor), has been explored in various cell types and intracellular compartments including caveolae vesicles in plasma membrane. The existence of association of LDLR and IR has been proved in type-2 diabetes and diabetes associated obesity. The non-functionality of LDLR in conjugation with IR has been found as of a prime reason for developing LDL related atherosclerosis in insulin defunct system. Confocal microcopy and western blots are the major techniques used to explore this study.
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N. Chandra (2019) conducted an observational in Obesity and Type-2 Diabetes (n=45). Obesity and Type-2 Diabetes vs. Normal healthy subjects was evaluated on Association of Insulin Receptor (IR) and LDL Receptor (LDLR) and receptor tyrosine phosphorylation. Obesity and type-2 diabetes are associated with a complex adherence of insulin and LDL receptors on the cell membrane, which reduces insulin receptor tyrosine phosphorylation and impairs LDL clearance.
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