Why the study?
Does amiodarone potentiate the anticoagulant effect of warfarin?
Does amiodarone potentiate the anticoagulant effect of warfarin?
Amiodarone potentiates the anticoagulant effect of warfarin, necessitating a 50% reduction in the warfarin maintenance dose when the two drugs are co-administered.
May support closer INR monitoring with amiodarone-warfarin co-use; leaves open optimal dosing in broader populations.
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
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Hamer et al. (1982) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: