Why the study?
Does aerobic exercise training improve flow-mediated dilation in patients with heart failure?
Meta-Analysis (n=458)
Does aerobic exercise training improve flow-mediated dilation in patients with heart failure?
Both moderate and vigorous aerobic exercise training significantly improve endothelial function, as measured by flow-mediated dilation, in patients with heart failure.
Supports aerobic exercise in heart failure management; confirms endothelial benefits across moderate and vigorous intensities.
Objective. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and aerobic exercise improves FMD in heart failure patients. The aim of this meta-analysis is to quantify the effect of aerobic training intensity on FMD in patients with heart failure. Background. A large number of studies now exist that examine endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of the aerobic training intensity on endothelial function. Methods. We conducted database searches (PubMed, Embase, ProQuest, and Cochrane Trials Register to June 30, 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, and flow-mediated dilation (FMD). Results. The 13 included studies provided a total of 458 participants, 264 in intervention groups, and 194 in nonexercising control groups. Both vigorous and moderate intensity aerobic training significantly improved FMD. Conclusion. Overall both vigorous and moderate aerobic exercise training improved FMD in patients with heart failure.
No takes yet. Share an insight, caveat, or question.
Pearson et al. (2017) conducted a meta-analysis in heart failure (n=458). Aerobic training vs. nonexercising control was evaluated on Flow-mediated dilation (FMD).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: