Key result
Aerobic exercise significantly improved flow-mediated dilation in prehypertensive and hypertensive patients (WMD 2.23; 95% CI 1.20-3.26; P<0.0001).
Why the study?
The study was conducted to evaluate the effect of aerobic exercise on endothelial function in hypertensive and prehypertensive patients, and to determine the optimal exercise duration and intensity.
Does aerobic exercise improve endothelial function in hypertensive and prehypertensive patients?
Meta-Analysis
Does aerobic exercise improve endothelial function in hypertensive and prehypertensive patients?
Moderate to vigorous aerobic exercise for at least 12 weeks significantly improves endothelial function in patients with prehypertension and hypertension.
Answers are grounded in this paper and cite their sources.
Supports aerobic exercise in hypertension management for endothelial benefits; extends prior evidence with new RCT data.
Our objective was to explore the effect of aerobic exercise on endothelial function in hypertensive and prehypertensive patients, and to ascertain the optimal duration and intensity of aerobic exercise. Data were synthesized using a random effects model to calculate the weighted mean difference (WMD) and 95% confidence interval (CI). Fifteen studies met the inclusion criteria. Aerobic exercise was found to significantly improve flow-mediated dilation (FMD) in prehypertensive and hypertensive patients (WMD, 2.23; 95% CI, 1.20-3.26; P < 0.0001; I2 = 90%). Aerobic exercise, undertaken at a moderate or, even better, vigorous intensity, and lasting no less than 12 weeks, is an effective approach to improve flow-mediated dilation (FMD) in prehypertensive and hypertensive patients. The effect of aerobic exercise on endothelial function is influenced by participant characteristics: a better health status, a younger age, a larger basal body mass index, and a larger basal FMD were associated with larger improvement in FMD.
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Li et al. (2025) conducted a meta-analysis in Hypertension and prehypertension. Aerobic exercise was evaluated on Flow-mediated dilation (FMD) (WMD 2.23, 95% CI 1.20-3.26, p=< 0.0001). Aerobic exercise significantly improved flow-mediated dilation in prehypertensive and hypertensive patients (WMD 2.23; 95% CI 1.20-3.26; P<0.0001).
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