Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences

Q: What is the clinical evidence from this study?

Study design: Review. Population: SARS-CoV-2 infection. Intervention: SARS-CoV-2 infection.

Agnieszka Dettlaff‐Pokora; Julian Świerczyński

doi:10.3390/ijms22094503

April 26, 2021International Journal of Molecular SciencesOpen Access

Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences

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Key Points

To describe the mechanism by which SARS-CoV-2 binding to ACE2 disrupts the renin-angiotensin-aldosterone system and to evaluate its clinical impact on lung injury.
Mechanistic synthesis of ACE2 enzymatic pathways involving the conversion of angiotensin 2 to angiotensin (1-7) and angiotensin (1-9) synthesis.
Evaluation of viral entry dynamics, cellular internalization, and downstream degradation of membrane-bound ACE2 during infection.
SARS-CoV-2 binding triggers the internalization and degradation of cell-surface ACE2, markedly diminishing its enzymatic activity.
Loss of functional ACE2 reduces protective, vasodilating angiotensin (1-7) while increasing vasoconstrictive, atherogenic angiotensin 2, driving pulmonary tissue damage.

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Population

Patients infected with SARS-CoV-2

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Implication

SARS-CoV-2 infection disrupts the RAAS balance by downregulating ACE2, potentially exacerbating lung injury through increased angiotensin 2 levels.

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Dettlaff‐Pokora et al. (2021) conducted a review in SARS-CoV-2 infection. SARS-CoV-2 infection was evaluated.

synapsesocial.com/papers/6a98bc79b0871bb756e10768 https://doi.org/10.3390/ijms22094503

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Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences

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Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Dysregulation of the Renin-Angiotensin-Aldosterone System (RAA) in Patients Infected with SARS-CoV-2-Possible Clinical Consequences

Figures

Key Points

Structured PICO

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Implication

Abstract

Discussion

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