Key result
Statin treatment was associated with the development of inflammatory myopathy in three patients, with multiple mitochondrial DNA deletions found in two of them.
Why the study?
Can statins induce an immune-mediated inflammatory myopathy?
Case Report (n=3)
Can statins induce an immune-mediated inflammatory myopathy?
This case series highlights the rare potential for statins to induce an immune-mediated inflammatory myopathy, possibly involving mitochondrial DNA deletions.
Statin-associated inflammatory myopathy warrants clinical vigilance; leaves open whether mitochondrial DNA deletions are causal or coincidental.
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
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Kuncová et al. (2012) conducted a case report in Inflammatory myopathy (n=3). Statins was evaluated on Development of inflammatory myopathy and mitochondrial DNA deletions. Statin treatment was associated with the development of inflammatory myopathy in three patients, with multiple mitochondrial DNA deletions found in two of them.
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