Key result
Statin treatment was associated with the development of inflammatory myopathy in three patients, with multiple mitochondrial DNA deletions found in two of them.
Why the study?
Can statins induce an immune-mediated response directed against skeletal muscle resulting in inflammatory myopathy?
Case Report (n=3)
Can statins induce an immune-mediated response directed against skeletal muscle resulting in inflammatory myopathy?
Statins may be associated with the development of inflammatory myopathy and mitochondrial DNA deletions in rare cases.
Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
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Kuncová et al. (2014) conducted a case report in Inflammatory myopathy (n=3). Statins was evaluated on Development of inflammatory myopathy and mitochondrial DNA deletions. Statin treatment was associated with the development of inflammatory myopathy in three patients, with multiple mitochondrial DNA deletions found in two of them.
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