Key result
The LAmbre device successfully occluded large left atrial appendages (ostium ≥31 mm) in 89.9% of cases, demonstrating feasibility and safety with no device embolisation.
Why the study?
Common LAAO devices rely on oversizing and cannot occlude large LAA (ostium or landing zone ≥31 mm), whereas the LAmbre device may potentially occlude ostia up to 40 mm.
Does the LAmbre device achieve successful occlusion in patients with large left atrial appendages?
Observational (n=27)
Yes
Does the LAmbre device achieve successful occlusion in patients with large left atrial appendages?
The LAmbre device demonstrates feasibility and safety for occluding large left atrial appendages (ostium ≥31 mm), providing a viable option for patients ineligible for standard LAAO devices.
Answers are grounded in this paper and cite their sources.
Supports LAmbre feasibility for large LAAs; leaves open need for RCTs before changing practice.
Introduction The commonly used left atrial appendage (LAA) occlusion (LAAO) devices, the WATCHMAN™ (Boston Scientific, Marlborough, MA, USA) and the AMPLATZER™ Amulet™ (Abbott Vascular, Santa Clara, CA, USA), both rely on oversizing for stabilisation. Therefore, occluding large LAA (ostium ≥31 mm for the WATCHMAN or landing zone ≥31 mm for the AMPLATZER Amulet) is not possible. The LAmbre™ device (Lifetech Scientific [Shenzhen] Co., Ltd. Shenzhen, China) has an additional stabilisation mechanism which catches the LAA trabeculations using its eight claws1. This potentially allows LAmbre to occlude a large LAA with an ostium up to 40 mm, ...
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So et al. (2021) conducted an observational in Large left atrial appendage (n=27). LAmbre device was evaluated on Device success rate (successful device implantation without significant peri-device leak >5 mm). The LAmbre device successfully occluded large left atrial appendages (ostium ≥31 mm) in 89.9% of cases, demonstrating feasibility and safety with no device embolisation.
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