Key result
The EMMACE longitudinal cohort study established a linked database of 14,899 patients hospitalized for myocardial infarction in England to investigate 10-year health trajectories and outcomes.
Why the study?
The study was designed to investigate health trajectories of individuals following hospitalization for myocardial infarction.
Cohort (n=14,899)
Yes
Answers are grounded in this paper and cite their sources.
The EMMACE cohort profile describes a nationwide prospective study of 14,899 MI patients in England, designed to evaluate long-term health trajectories, medication adherence, and quality of life up to 10 years post-MI.
AIMS: The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE) longitudinal cohort study aims to investigate health trajectories of individuals following hospitalization for myocardial infarction (MI). METHODS AND RESULTS: EMMACE is a linked multicentre prospective cohort study of 14 899 patients with MI admitted to 77 hospitals in England who participated in the EMMACE-3 and -4 studies between 1st November 2011 and 24th June 2015. Long-term follow-up of the EMMACE cohorts was conducted through the EMMACE-XL (27th September 2020 to 31st March 2022) and EMMACE-XXL (1st July 2021 to 1st July 2023) studies. EMMACE collected individual participant data for health-related quality of life (HRQoL) measured by three-level EuroQol five-dimension and visual analogy scale at admission, 1 month, 6 months, 12 months, and 10 years follow-up, as well as medications, medication adherence, beliefs about medicines, Satisfaction with Information about Medicines Scale, and illness perceptions. Participant data were deterministically linked to the Myocardial Infarction National Audit Project (MINAP) for information on baseline treatments and comorbidities, Hospital Episode Statistics Admitted Patient Care (for cause-specific hospitalization data), and the Office for National Statistics (for mortality data) up to 2020. CONCLUSION: EMMACE is a nationwide prospective cohort that will provide unique insights into fatal and non-fatal outcomes, medication adherence, and HRQoL following MI.Trial registration: ClinicalTrials.gov NCT01808027 and NCT01819103.
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Munyombwe et al. (2023) conducted a cohort in Myocardial infarction (n=14,899). Myocardial infarction was evaluated on Health trajectories, fatal and non-fatal outcomes, medication adherence, and health-related quality of life. The EMMACE longitudinal cohort study established a linked database of 14,899 patients hospitalized for myocardial infarction in England to investigate 10-year health trajectories and outcomes.
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