Key result
Epigenetic mechanisms, including DNA methylation, histone modification, and microRNA, play a pivotal role in the genesis of atrial fibrillation and have potential as new biomarkers.
Why the study?
The search for biomarkers in atrial fibrillation is ongoing, and epigenetic mechanisms may help explain gaps in understanding how cardiac conditions, behavioral factors, and environmental factors lead to AF genesis.
What is the role of epigenetic mechanisms as potential biomarkers in atrial fibrillation?
What is the role of epigenetic mechanisms as potential biomarkers in atrial fibrillation?
Epigenetic mechanisms such as DNA methylation, histone modification, and microRNAs offer potential new avenues for early biomarker development in atrial fibrillation.
Epigenetic mechanisms may support early AF biomarker development; hypothesis-generating and requires prospective validation before clinical adoption.
Atrial fibrillation (AF) remains the center of attention in cardiology and vascular medicine, besides coronary artery disease (CAD) and heart failure (HF). Not only how to manage the disease, but how to prevent it also attract the interest of the researcher. A biomarker is still a hot topic in AF. Although the current recommendation did not place biomarkers in a central role, the search for perfect biomarkers for AF is still ongoing. The epigenetic mechanism seems to have a pivotal role in explaining the gap in AF mechanism understanding. How previous cardiac condition, behavioral factor, and environmental factor interact with each other and result in the genesis of AF can be explained by an epigenetic mechanism. Epigenetic process altered the gene expression and, in the future, will result in the development of the disease. Three epigenetic mechanisms that had been identified are DNA methylation, histone modification, and microRNA (miRNA). Identification of these early changes is the subject of epigenetic biomarkers. This review will discuss the basic understanding of the epigenetic mechanism in AF and its potential role to be the new biomarkers.
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Rizal et al. (2019) conducted a review in Atrial fibrillation. Epigenetic mechanisms (DNA methylation, histone modification, microRNA) was evaluated. Epigenetic mechanisms, including DNA methylation, histone modification, and microRNA, play a pivotal role in the genesis of atrial fibrillation and have potential as new biomarkers.
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