Key result
Large-scale genomic and epigenomic approaches broaden understanding of molecular drivers in AF and its progression.
Why the study?
Despite extensive study, the molecular mechanisms responsible for atrial fibrillation and disease progression remain incompletely understood.
Understanding genomic and epigenomic changes during atrial fibrillation chronification is essential for designing novel treatments.
May identify novel AF targets; leaves open clinical translation pending prospective validation.
Atrial fibrillation is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. Despite years of study, we still do not have a full comprehension of the molecular mechanism responsible for the disease. The recent implementation of large-scale approaches in both patient samples, population studies and animal models has helped us to broaden our knowledge on the molecular drivers responsible for AF and on the mechanisms behind disease progression. Understanding genomic and epigenomic changes that take place during chronification of AF will prove essential to design novel treatments leading to improved patient care.
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Victorino et al. (2021) conducted a review in Atrial fibrillation. Large-scale genomic and epigenomic approaches are broadening our understanding of the molecular drivers of atrial fibrillation and its progression.
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