Why the study?
Recent discoveries of post-transcriptional regulatory mechanisms in heart development and arrhythmogenesis motivated a current review of AF-related epigenetic regulatory networks.
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Design
Review
Supports hypothesis generation on AF epigenetic mechanisms; leaves open clinical translation pending prospective validation.
-handling abnormalities, and structural remodeling. Genome-wide association studies (GWAS) have uncovered over 100 genetic loci associated with AF. Most of these loci point to ion channels, distinct cardiac-enriched transcription factors, as well as to other regulatory genes. Recently, the discovery of post-transcriptional regulatory mechanisms, involving non-coding RNAs (especially microRNAs), DNA methylation, and histone modification, has allowed to decipher how a normal heart develops and which modifications are involved in reshaping the processes leading to arrhythmias. This review aims to provide a current state of the field regarding the identification and functional characterization of AF-related epigenetic regulatory networks.
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Lozano-Velasco et al. (2020) studied this question.
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