Key result
Treatment with GTS-21 significantly decreased the average Murine Sepsis Score (MD -1.84, p=0.039) and pro-inflammatory cytokines in septic rats compared to the model group.
Why the study?
To investigate the role of the cholinergic anti-inflammatory pathway in the neuro-regulation of inflammatory and immune responses in the early stage of sepsis.
Population
Septic rats
Authors
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Supports cholinergic pathway in rat sepsis model; leaves open translation to human therapy.
Mean Difference: -1.84 (95% CI -3.621–-0.054)
Absolute Event Rate: 17.64% vs 19.48%
p-value: p=0.039
The cholinergic anti-inflammatory pathway plays a negative regulatory role in early inflammatory and immune responses to sepsis in rats, which can be partially reflected by heart rate variability.
Li et al. (2020) studied Sepsis (n=64). GTS-21 vs. Model group (piperacillin + normal saline) was evaluated on Average Murine Sepsis Score (MSS) (MD -1.84, 95% CI -3.621 to -0.054, p=0.039). Treatment with GTS-21 significantly decreased the average Murine Sepsis Score (MD -1.84, p=0.039) and pro-inflammatory cytokines in septic rats compared to the model group.
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