Key result
Sepsis induced significant apoptosis and inactiveness of cholinergic and catecholaminergic neurons in the Medullary Visceral Zone of rats, inhibiting the cholinergic anti-inflammatory pathway.
Why the study?
How sepsis affects the medullary visceral zone and leads to uncontrolled inflammation remained unclear.
Does modulation of the cholinergic anti-inflammatory pathway with α7nAChR agonists or antagonists alter systemic inflammation and MVZ neuron apoptosis in rat models of sepsis?
Population
Rat models of sepsis prepared by cecal ligation and puncture
Comparison
alpha7nAChR agonist GTS-21 vs alpha7nAChR antagonist MLA
Design
Animal study
Authors
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Hypothesis-generating for α7nAChR agonism in sepsis; clinical translation untested.
Does modulation of the cholinergic anti-inflammatory pathway with α7nAChR agonists or antagonists alter systemic inflammation and MVZ neuron apoptosis in rat models of sepsis?
Sepsis induces apoptosis of neurons in the Medullary Visceral Zone, inhibiting the cholinergic anti-inflammatory pathway, a process that can be modulated by α7nAChR targeted therapies.
Li et al. (2020) studied Sepsis. Sepsis was evaluated on Inflammatory level, mortality, and Murine Sepsis Score. Sepsis induced significant apoptosis and inactiveness of cholinergic and catecholaminergic neurons in the Medullary Visceral Zone of rats, inhibiting the cholinergic anti-inflammatory pathway.
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